Variation Browser
DownloadReceptor | Position | GPCRdb | Segment | Variant | Mutation type | Allele Frequency | Allele Count | Allele Number | Homozygotes | SIFT score | PolyPhen score | Functional annotation |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Receptor | Position | GPCRdb | Segment | Variant | Mutation Type | Allele Frequency | Allele Count | Allele Number | Homozygotes | SIFT score | PolyPhen score | Functional annotation |
oprd_human | 209 | 5.34x35 | TM5 | W => Ter | stop gained | 5.047e-05 | 6 | 118884 | 0 | None | None | |
oprd_human | 251 | 6.25x25 | TM6 | E => ArgfsTer227 | frameshift | 8.492e-06 | 1 | 117754 | 0 | None | None | GP (contact) |
oprd_human | 337 | C-term | C => Ter | stop gained | 4.254e-05 | 3 | 70520 | 0 | None | None | ||
oprd_human | 356 | C-term | R => ProfsTer119 | frameshift | 2.775e-05 | 1 | 36042 | 0 | None | None | ||
oprd_human | 10 | N-term | E => K | missense | 0.0002279 | 1 | 4388 | 0 | 0.7 | 0.001 | ||
oprd_human | 14 | N-term | P => L | missense | 0.0003863 | 3 | 7766 | 0 | 0.3 | 0.0 | ||
oprd_human | 22 | N-term | A => T | missense | 0.0001888 | 2 | 10596 | 0 | 0.5 | 0.0 | ||
oprd_human | 24 | N-term | P => A | missense | 0.0001817 | 2 | 11006 | 0 | 0.13 | 0.001 | ||
oprd_human | 27 | N-term | C => F | missense | 0.9198 | 23407 | 25448 | 10722 | 0.72 | 0.0 | ||
oprd_human | 44 | 1.27x27 | TM1 | S => L | missense | 2.23e-05 | 1 | 44836 | 0 | 0.23 | 0.012 | |
oprd_human | 45 | 1.28x28 | TM1 | S => T | missense | 2.112e-05 | 1 | 47358 | 0 | 0.15 | 0.483 | |
oprd_human | 48 | 1.31x31 | TM1 | L => Q | missense | 0.0001976 | 12 | 60728 | 0 | 0.08 | 0.902 | |
oprd_human | 48 | 1.31x31 | TM1 | L => P | missense | 1.647e-05 | 1 | 60728 | 0 | 0.1 | 0.902 | |
oprd_human | 52 | 1.35x35 | TM1 | I => V | missense | 0.00803 | 611 | 76086 | 24 | 0.05 | 0.141 | |
oprd_human | 55 | 1.38x38 | TM1 | L => F | missense | 1.185e-05 | 1 | 84388 | 0 | 0.01 | 0.86 | |
oprd_human | 61 | 1.44x44 | TM1 | A => S | missense | 1.085e-05 | 1 | 92160 | 0 | 0.06 | 0.03 | |
oprd_human | 65 | 1.48x48 | TM1 | L => V | missense | 1.064e-05 | 1 | 94008 | 0 | 1.0 | 0.01 | |
oprd_human | 68 | 1.51x51 | TM1 | V => L | missense | 6.415e-05 | 6 | 93532 | 0 | 0.45 | 0.003 | |
oprd_human | 71 | 1.54x54 | TM1 | M => T | missense | 1.099e-05 | 1 | 91000 | 0 | 0.0 | 0.365 | |
oprd_human | 72 | 1.55x55 | TM1 | F => L | missense | 1.115e-05 | 1 | 89678 | 0 | 0.0 | 0.403 | |
oprd_human | 73 | 1.56x56 | TM1 | G => V | missense | 1.141e-05 | 1 | 87680 | 0 | 1.0 | 0.011 | |
oprd_human | 76 | 1.59x59 | TM1 | R => W | missense | 1.199e-05 | 1 | 83418 | 0 | 0.0 | 0.944 | |
oprd_human | 79 | 12.49x49 | ICL1 | K => E | missense | 1.675e-05 | 2 | 119386 | 0 | 0.0 | 0.975 | |
oprd_human | 79 | 12.49x49 | ICL1 | K => R | missense | 8.371e-06 | 1 | 119454 | 0 | 0.0 | 0.888 | |
oprd_human | 83 | 2.38x38 | TM2 | A => P | missense | 8.333e-06 | 1 | 120010 | 0 | 0.01 | 0.45 | |
oprd_human | 95 | 2.50x50 | TM2 | D => N | missense | 8.28e-06 | 1 | 120774 | 0 | 0.0 | 0.995 | |
oprd_human | 96 | 2.51x51 | TM2 | A => V | missense | 8.277e-06 | 1 | 120822 | 0 | 0.19 | 0.372 | |
oprd_human | 96 | 2.51x51 | TM2 | A => G | missense | 8.277e-06 | 1 | 120822 | 0 | 0.0 | 0.72 | |
oprd_human | 100 | 2.55x55 | TM2 | S => T | missense | 8.268e-06 | 1 | 120954 | 0 | 0.48 | 0.023 | |
oprd_human | 100 | 2.55x55 | TM2 | S => R | missense | 8.267e-06 | 1 | 120958 | 0 | 0.03 | 0.778 | |
oprd_human | 101 | 2.56x56 | TM2 | T => M | missense | 8.267e-06 | 1 | 120968 | 0 | 0.0 | 0.877 | |
oprd_human | 106 | 2.61x61 | TM2 | S => G | missense | 1.652e-05 | 2 | 121096 | 0 | 0.33 | 0.115 | |
oprd_human | 107 | 2.62x62 | TM2 | A => V | missense | 8.257e-06 | 1 | 121104 | 0 | 0.34 | 0.116 | |
oprd_human | 113 | 23.49x49 | ECL1 | T => M | missense | 1.65e-05 | 2 | 121180 | 0 | 0.22 | 0.657 | |
oprd_human | 113 | 23.49x49 | ECL1 | T => R | missense | 1.65e-05 | 2 | 121180 | 0 | 0.43 | 0.932 | |
oprd_human | 117 | 3.21x21 | TM3 | G => S | missense | 1.65e-05 | 2 | 121236 | 0 | 0.04 | 0.945 | |
oprd_human | 118 | 3.22x22 | TM3 | E => K | missense | 3.299e-05 | 4 | 121254 | 0 | 0.38 | 0.03 | |
oprd_human | 120 | 3.24x24 | TM3 | L => I | missense | 2.474e-05 | 3 | 121280 | 0 | 0.11 | 0.18 | |
oprd_human | 121 | 3.25x25 | TM3 | C => R | missense | 1.649e-05 | 2 | 121288 | 0 | 0.0 | 0.989 | |
oprd_human | 122 | 3.26x26 | TM3 | K => E | missense | 8.244e-06 | 1 | 121296 | 0 | 0.0 | 0.985 | |
oprd_human | 122 | 3.26x26 | TM3 | K => R | missense | 8.244e-06 | 1 | 121300 | 0 | 0.49 | 0.889 | |
oprd_human | 127 | 3.31x31 | TM3 | I => V | missense | 8.241e-06 | 1 | 121342 | 0 | 0.49 | 0.116 | |
oprd_human | 129 | 3.33x33 | TM3 | Y => C | missense | 8.24e-06 | 1 | 121354 | 0 | 0.09 | 0.35 | LB (polar (hydrogen bond), Van der Waals, hydrophobic, aromatic (face-to-edge)) |
oprd_human | 132 | 3.36x36 | TM3 | M => I | missense | 8.24e-06 | 1 | 121362 | 0 | 0.0 | 0.533 | LB (hydrophobic, Van der Waals) |
oprd_human | 142 | 3.46x46 | TM3 | M => L | missense | 2.472e-05 | 3 | 121376 | 0 | 0.26 | 0.938 | |
oprd_human | 142 | 3.46x46 | TM3 | M => I | missense | 8.239e-06 | 1 | 121378 | 0 | 0.0 | 0.995 | |
oprd_human | 146 | 3.50x50 | TM3 | R => C | missense | 8.24e-06 | 1 | 121366 | 0 | 0.0 | 1.0 | SodiumPocket MicroSwitch GP (contact) |
oprd_human | 146 | 3.50x50 | TM3 | R => H | missense | 1.648e-05 | 2 | 121368 | 0 | 0.0 | 1.0 | SodiumPocket MicroSwitch GP (contact) |
oprd_human | 156 | 34.53x53 | ICL2 | A => S | missense | 8.245e-06 | 1 | 121286 | 0 | 0.16 | 0.426 | GP (contact) |
oprd_human | 158 | 34.55x55 | ICL2 | D => E | missense | 8.25e-06 | 1 | 121210 | 0 | 0.06 | 0.316 | GP (contact) |
oprd_human | 160 | 34.57x57 | ICL2 | R => C | missense | 8.253e-06 | 1 | 121162 | 0 | 0.02 | 1.0 | GP (contact) |
oprd_human | 160 | 34.57x57 | ICL2 | R => H | missense | 8.255e-06 | 1 | 121146 | 0 | 0.0 | 0.999 | GP (contact) |
oprd_human | 161 | 4.38x38 | TM4 | T => M | missense | 8.254e-06 | 1 | 121156 | 0 | 0.01 | 0.999 | |
oprd_human | 165 | 4.42x42 | TM4 | A => V | missense | 8.263e-06 | 1 | 121018 | 0 | 0.0 | 0.999 | |
oprd_human | 171 | 4.48x48 | TM4 | C => R | missense | 1.658e-05 | 2 | 120614 | 0 | 0.0 | 0.957 | |
oprd_human | 181 | 4.58x58 | TM4 | V => M | missense | 8.481e-06 | 1 | 117914 | 0 | 0.04 | 0.715 | |
oprd_human | 181 | 4.58x58 | TM4 | V => L | missense | 8.481e-06 | 1 | 117914 | 0 | 1.0 | 0.081 | |
oprd_human | 183 | 4.60x60 | TM4 | I => V | missense | 0.0001626 | 19 | 116816 | 0 | 0.58 | 0.076 | |
oprd_human | 186 | 4.63x63 | TM4 | M => V | missense | 8.755e-06 | 1 | 114218 | 0 | 0.02 | 0.275 | |
oprd_human | 186 | 4.63x63 | TM4 | M => K | missense | 1.758e-05 | 2 | 113762 | 0 | 0.0 | 0.864 | |
oprd_human | 190 | ECL2 | R => H | missense | 1.921e-05 | 2 | 104120 | 0 | 0.01 | 0.006 | ||
oprd_human | 192 | ECL2 | R => W | missense | 9.898e-06 | 1 | 101028 | 0 | 0.0 | 0.663 | ||
oprd_human | 192 | ECL2 | R => Q | missense | 2.988e-05 | 3 | 100392 | 0 | 0.25 | 0.013 | ||
oprd_human | 194 | ECL2 | G => R | missense | 8.97e-06 | 1 | 111484 | 0 | 0.01 | 0.936 | ||
oprd_human | 197 | ECL2 | V => M | missense | 8.82e-06 | 1 | 113374 | 0 | 0.25 | 0.073 | ||
oprd_human | 208 | 5.33x34 | TM5 | Y => C | missense | 8.429e-06 | 1 | 118636 | 0 | 0.02 | 0.997 | |
oprd_human | 213 | 5.38x39 | TM5 | T => S | missense | 8.328e-06 | 1 | 120074 | 0 | 0.0 | 0.721 | PTM (Phosphorylation) |
oprd_human | 218 | 5.43x44 | TM5 | F => L | missense | 8.288e-06 | 1 | 120658 | 0 | 0.0 | 0.972 | |
oprd_human | 220 | 5.45x46 | TM5 | F => L | missense | 1.656e-05 | 2 | 120740 | 0 | 0.4 | 0.156 | |
oprd_human | 221 | 5.46x461 | TM5 | A => S | missense | 8.281e-06 | 1 | 120756 | 0 | 0.36 | 0.712 | |
oprd_human | 229 | 5.54x54 | TM5 | I => T | missense | 8.286e-06 | 1 | 120692 | 0 | 0.0 | 0.993 | |
oprd_human | 231 | 5.56x56 | TM5 | V => L | missense | 8.29e-06 | 1 | 120630 | 0 | 0.66 | 0.48 | |
oprd_human | 236 | 5.61x61 | TM5 | M => V | missense | 8.305e-06 | 1 | 120404 | 0 | 0.02 | 0.421 | GP (contact) |
oprd_human | 237 | 5.62x62 | TM5 | L => P | missense | 8.316e-06 | 1 | 120256 | 0 | 0.0 | 0.949 | |
oprd_human | 242 | 5.67x67 | TM5 | S => R | missense | 8.35e-06 | 1 | 119762 | 0 | 0.03 | 0.008 | GP (contact) |
oprd_human | 246 | ICL3 | L => P | missense | 2.521e-05 | 3 | 119004 | 0 | 0.02 | 0.515 | ||
oprd_human | 247 | ICL3 | S => W | missense | 8.425e-06 | 1 | 118696 | 0 | 0.0 | 0.999 | ||
oprd_human | 250 | 6.24x24 | TM6 | K => E | missense | 2.547e-05 | 3 | 117774 | 0 | 0.01 | 0.845 | |
oprd_human | 250 | 6.24x24 | TM6 | K => R | missense | 0.0001698 | 20 | 117754 | 0 | 0.65 | 0.139 | |
oprd_human | 253 | 6.27x27 | TM6 | D => H | missense | 2.59e-05 | 3 | 115822 | 0 | 0.01 | 0.87 | |
oprd_human | 254 | 6.28x28 | TM6 | R => C | missense | 8.721e-06 | 1 | 114668 | 0 | 0.0 | 0.999 | GP (contact) |
oprd_human | 261 | 6.35x35 | TM6 | R => L | missense | 0.0002822 | 31 | 109862 | 0 | 0.08 | 0.994 | |
oprd_human | 263 | 6.37x37 | TM6 | V => L | missense | 9.17e-06 | 1 | 109054 | 0 | 0.0 | 0.954 | GP (contact) |
oprd_human | 265 | 6.39x39 | TM6 | V => M | missense | 9.267e-06 | 1 | 107906 | 0 | 0.21 | 0.978 | |
oprd_human | 269 | 6.43x43 | TM6 | A => S | missense | 1.905e-05 | 2 | 104976 | 0 | 0.0 | 0.928 | |
oprd_human | 271 | 6.45x45 | TM6 | V => L | missense | 3.847e-05 | 4 | 103968 | 0 | 0.02 | 0.854 | |
oprd_human | 271 | 6.45x45 | TM6 | V => L | missense | 1.924e-05 | 2 | 103968 | 0 | 0.02 | 0.854 | |
oprd_human | 275 | 6.49x49 | TM6 | A => T | missense | 9.745e-06 | 1 | 102620 | 0 | 1.0 | 0.008 | |
oprd_human | 275 | 6.49x49 | TM6 | A => V | missense | 2.943e-05 | 3 | 101926 | 0 | 0.05 | 0.264 | |
oprd_human | 275 | 6.49x49 | TM6 | A => G | missense | 9.811e-06 | 1 | 101926 | 0 | 0.01 | 0.664 | |
oprd_human | 282 | 6.56x56 | TM6 | I => T | missense | 2.962e-05 | 3 | 101286 | 0 | 0.0 | 0.906 | |
oprd_human | 292 | ECL3 | R => C | missense | 3.04e-05 | 3 | 98690 | 0 | 0.05 | 0.608 | ||
oprd_human | 294 | 7.29x28 | TM7 | P => Q | missense | 1.011e-05 | 1 | 98954 | 0 | 0.11 | 0.128 | |
oprd_human | 296 | 7.31x30 | TM7 | V => M | missense | 2.017e-05 | 2 | 99172 | 0 | 0.07 | 0.491 | |
oprd_human | 296 | 7.31x30 | TM7 | V => L | missense | 1.008e-05 | 1 | 99172 | 0 | 0.28 | 0.042 | |
oprd_human | 309 | 7.44x43 | TM7 | A => T | missense | 0.01309 | 1353 | 103352 | 52 | 0.93 | 0.1 | SodiumPocket MicroSwitch |
oprd_human | 310 | 7.45x45 | TM7 | N => H | missense | 9.656e-06 | 1 | 103558 | 0 | 0.0 | 1.0 | |
oprd_human | 310 | 7.45x45 | TM7 | N => S | missense | 9.661e-06 | 1 | 103514 | 0 | 0.0 | 1.0 | |
oprd_human | 324 | 8.49x49 | H8 | N => S | missense | 1.063e-05 | 1 | 94090 | 0 | 0.02 | 0.906 | GP (contact) |
oprd_human | 330 | 8.55x55 | H8 | R => C | missense | 1.175e-05 | 1 | 85086 | 0 | 0.0 | 0.947 | |
oprd_human | 334 | 8.59x59 | H8 | R => L | missense | 1.31e-05 | 1 | 76332 | 0 | 1.0 | 0.003 | |
oprd_human | 339 | C-term | R => C | missense | 2.933e-05 | 2 | 68196 | 0 | 0.04 | 0.339 | ||
oprd_human | 340 | C-term | P => S | missense | 6.024e-05 | 4 | 66402 | 0 | 0.73 | 0.001 | ||
oprd_human | 343 | C-term | S => G | missense | 1.663e-05 | 1 | 60124 | 0 | 0.44 | 0.0 | ||
oprd_human | 346 | C-term | S => T | missense | 1.929e-05 | 1 | 51838 | 0 | 0.29 | 0.001 | ||
oprd_human | 347 | C-term | R => C | missense | 0.0001369 | 7 | 51118 | 0 | 0.01 | 0.008 | ||
oprd_human | 347 | C-term | R => H | missense | 7.908e-05 | 4 | 50582 | 0 | 0.02 | 0.781 | ||
oprd_human | 349 | C-term | R => H | missense | 2.146e-05 | 1 | 46592 | 0 | 0.02 | 0.011 | ||
oprd_human | 361 | C-term | T => N | missense | 0.0001526 | 4 | 26218 | 0 | 0.28 | 0.016 | PTM (Phosphorylation (ADRBK1)) | |
oprd_human | 365 | C-term | G => D | missense | 0.0003023 | 4 | 13230 | 0 | 0.03 | 0.001 | ||
oprd_human | 366 | C-term | P => L | missense | 0.0002922 | 3 | 10268 | 0 | 0.2 | 0.004 | ||
oprd_human | 367 | C-term | G => S | missense | 0.0002143 | 2 | 9334 | 0 | 0.44 | 0.062 |
Residue
- deleterious missense variants are shown in red
- tolerated missense variants are shown in green
- loss of function mutations ('stop gained' or 'frameshift' in the coding region) are shown in blue